compound introduction
Falcarindiol 是从胡萝卜中得到的聚乙炔，具有抗分歧杆菌 (antimycobacterial) 作用，对 Mycobacterium tuberculosis H37Ra 的最低抑制浓度 MIC 和 IC50 值分别为 24 μM 和 6 μM。具有抗肿瘤和抗炎作用。 Information Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression ofinducible nitric oxide synthase (iNOS),tumor necrosis factor alpha (TNFα),interleukin-6 (IL-6), andinterleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation ofJNK,ERK,STAT1, andSTAT3signaling molecules. Falnidamol is a pyrim Targets iNOS ; TNFα ; IL-6 ; IL-1β ; JNK 33670,
