Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种有效的氟喹诺酮类抗生素 (antibiotic)，具有广谱抗菌活性。Gatifloxacin hydrochloride (AM-1155 hydrochloride) 可抑制细菌 II 型拓扑异构酶 (type II topoisomerases) (IC50=13.8 μg/ml; 金黄色葡萄球菌拓扑异构酶 IV) 和大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)。Gatifloxacin hydrochloride (AM-1155 hydrochloride) 在动物模型中，可用于细菌性结膜炎的研究。 Information Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type IItopoisomeraseswith IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively. Targets S. aureus topoisomerase IV (Cell-free assay); E. coli DNA gyrase (Cell-free assay) Product description Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
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Gatifloxacin hydrochloride
CAS number：121577-32-0 molecular formula：C19H23ClFN3O4
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| Chinese alias | - | ||
| English alias | AMY17807 | NCGC00247879-01 | s5964 | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride | AM-1155 hydrochloride;CG5501 hydrochloride;BMS-206584 hydrochloride;PD135432 hydrochloride | gatifloxacin hyd | ||
| CAS number | 121577-32-0 | molecular formula | C19H23ClFN3O4 |
| molecular weight | 411.86 g/mol | Exact mass | - |
| PSA | 82.100 Ų | logp | -0.527 |
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