SC75741 是一种广泛，有效的 NF-κB 抑制剂，对 p65 的 IC50 为 200 nM。SC75741 可阻断 influenza viruses 复制。SC75741 通过损害 NF-κB 亚基 p65 的 DNA 结合，导致细胞因子，趋化因子和促凋亡因子的表达降低，抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白 (viralribonucleoproteins) 的核输出。 产品应用 SC75741 是强效的NF-κB抑制剂，其EC50为200 nM。SC75741 可有效地阻断流感病毒的传播。 Information SC75741 SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation. Targets NF-κB (Cell-based NF-κB reporter gene assay) 200 nM(EC50) In vitro SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants. In vivo SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection. Cell Research(from reference) Cell lines：Human PBMCs Concentrations：~50 μM Incubation Time：48 hours
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SC75741
CAS number：913822-46-5 molecular formula：C29H23N7O2S2
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| Chinese alias | - | ||
| English alias | 4-Thiazolecarboxamide,N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)- | 4SC-301, N-(5-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide | N-(6-Benzoyl-1H-benzimidazol-2- | ||
| CAS number | 913822-46-5 | molecular formula | C29H23N7O2S2 |
| molecular weight | 565.67 g/mol | Exact mass | ≥98% |
| PSA | 173.000 Ų | logp | 5.57 |
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