CAS number：1620458-09-4 molecular formula：C22H22FN5O7
Zoliflodacin (ETX0914;AZD0914) 是一种新型的螺旋嘧啶三酮，细菌DNA促旋酶/拓扑异构酶 抑制剂。Zoliflodacin 对革兰氏阳性和阴性生物具有有效的体外抗菌活性，对金黄色葡萄球菌的b>MIC90 值为0.25 μg/mL。 Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.
| Chinese alias | 佐利氟达星 | ||
| English alias | AC-35757 | FWL2263R77 | EXT-0914 | (4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]spiro[1,3-diazinane-5,8'-5,15-dioxa-2,14-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(17),10,12(16),13-tetraene]-2,4,6-trione | UNII-F | ||
| CAS number | 1620458-09-4 | molecular formula | C22H22FN5O7 |
| molecular weight | 487.44 g/mol | Exact mass | - |
| PSA | 143.000 Ų | logp | 1.3 |
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