Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. In Vitro Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Vaborbactam（RPX7009）
CAS number：1360457-46-0 molecular formula：C12H16BNO5S
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| Chinese alias | 伐伯巴坦 | 2-((3R,6S)-2-羟基-3-(2-(噻吩-2-基)乙酰胺基)-1,2-氧硼杂环己烷-6-基)乙酸 | ||
| English alias | 2-[(3R,6S)-2-hydroxy-3-[(2-thiophen-2-ylacetyl)amino]oxaborinan-6-yl]acetic acid | compound 9f [PMID: 25782055] | DTXSID901027690 | DB12107 | EN300-20818376 | VABORBACTAM [MI] | RPX7009 | 2-hydroxy-3R-[[2-(2-thienyl)acetyl]amino]-1,2-oxaborinane-6S-acetic | ||
| CAS number | 1360457-46-0 | molecular formula | C12H16BNO5S |
| molecular weight | 297.14 g/mol | Exact mass | - |
| PSA | 124.000 Ų | logp | - |
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