AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5 . AZD 2066 hydrate has antinociception effects. Appearance:Solid IC50& Target:mGluR5 In Vitro:AZD 2066 (1-10 μM) inhibits Ca 2+ response, with IC 50 s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively. AZD 2066 (1-10 μM) inhibits the oscillatory Ca 2+ response w In Vivo:AZD 2066 (0.03-30mg/kg; p.o.) shows discriminative effects in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (weighing 240-250 g)Dosage: 0.03, 0.1, 0.3, 1, 3, Biological Activity:AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5 . AZD 2066 hydrate has antinociception effects.
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AZD 2066 hydrate
CAS number：unknown molecular formula：C19H16ClN5O2.1/4H2O
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| Chinese alias | AZD2066 水合物 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C19H16ClN5O2.1/4H2O |
| molecular weight | 386.33 g/mol | Exact mass | - |
| PSA | - | logp | - |
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