Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor . Methoctramine tetrahydrochloride can inhibit Muscarine-induced bradycardia in vivo In Vitro Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner. Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation. Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Methoctramine (300 µg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:M2 muscarinic receptor
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Methoctramine tetrahydrochloride
CAS number：104807-46-7 molecular formula：C36H66Cl4N4O2
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| Chinese alias | 甲氧苄胺四盐酸盐 | ||
| English alias | N1,N1'-(octane-1,8-diyl)bis(N6-(2-methoxybenzyl)hexane-1,6-diamine) tetrahydrochloride | CHEBI:73452 | Tox21_500862 | Methoctramine tetrahydrochloride | 1,8-Octanediamine, N,N'-bis(6-(((2-methoxyphenyl)methyl)amino)hexyl)-, tetrahydrochloride | N,N'-bis{6 | ||
| CAS number | 104807-46-7 | molecular formula | C36H66Cl4N4O2 |
| molecular weight | 582.9014584 g/mol | Exact mass | ≥97% |
| PSA | 66.600 Ų | logp | - |
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