compound introduction
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K i of 67 nM, the IC 50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment. Pharmacokinetic Analysis ICR Male Mice 药代动力学分析 Plasma Intravenous Administration Intraperitoneal Administration T max (h) 0.08 0.25 T 1/2 (h) 0.77 1.06 C max (ng/mL) 33.07 156.44 AUC last (ng·h/mL) 28.31 143.27 CL (L/h/kg) 41.61 - V ss (L/kg) 32.43 - MRT (h) 0.79 0.93 F (%) 50.60
