compound introduction
LDN-193189 (DM3189) 2HCl是一种选择性 BMP 信号抑制剂，抑制 ALK1, ALK2, ALK3和 ALK6，在激酶测定中的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 抑制BMP I型受体ALK2和ALK3的转录活性，在C2C12细胞中IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。
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LDN 193189 dihydrochloride
CAS number：1435934-00-1 molecular formula：C25H24Cl2N6
overview
Specs
| Chinese alias | 4-[6-[4-(1-哌嗪基)苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉二盐酸盐 | LDN 193189 二盐酸盐 | ||
| English alias | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride | DM-3189 2HCl | ||
| CAS number | 1435934-00-1 | molecular formula | C25H24Cl2N6 |
| molecular weight | 479.4 g/mol | Exact mass | 10mM in Water |
| PSA | 58.400 Ų | logp | - |
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