CAS number：372196-77-5 molecular formula：C16H14BrN5O4S·HCl
PIK-75是一种p110α抑制剂，IC50为5.8 nM (比作用于p110β效果强200倍)，亚型特异性的突变体在Ser773，也有效抑制DNA-PK，IC50为2 nM。 PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.
| Chinese alias | - | ||
| English alias | (E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride | (E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide HCl | EX-A1440 | PIK-75, hydrochloride | Be | ||
| CAS number | 372196-77-5 | molecular formula | C16H14BrN5O4S·HCl |
| molecular weight | 488.74 g/mol | Exact mass | 2mM in DMSO |
| PSA | 121.000 Ų | logp | - |
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