Ivachtin（2- [4-甲基-8-（吗啉-4-基磺酰基）-1,3-二氧代-1,3-二氢-2H-吡咯并[3,4-c]喹啉-2-基]乙酸乙酯）是一种有效的，细胞可渗透的，可逆的，非竞争性的Caspase-3抑制剂（IC | 50 | = 23 nM）。也称为Caspase-3抑制剂VII。与Z-VAD-FMK相比，它具有比其他胱天蛋白酶高10-100倍的选择性和更高的抗凋亡活性。使用该抑制剂后，可以使用标准的凋亡检测方法检查处理过的细胞的凋亡证据。|对于荧光测定caspase-3活性，可提供试剂盒 Ivachtin (2-[4-Methyl-8-(morpholin-4-ylsulfon yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate) is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC|50|= 23 nM). Also called Caspase-3 Inhibitor VII. It has been shown to have 10-100 fold selectivity over other caspases and higher anti-apoptotic activity than Z-VAD-FMK . Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.|For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit
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Ivachtin
CAS number：745046-84-8 molecular formula：C20H21N3O7S
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| Chinese alias | - | ||
| English alias | Caspase-3 Inhibitor VII | VEB04684 | 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate | SCHEMBL526321 | BCP17017 | VU0012362-4 | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin- | ||
| CAS number | 745046-84-8 | molecular formula | C20H21N3O7S |
| molecular weight | 447.46 g/mol | Exact mass | - |
| PSA | 132.000 Ų | logp | 0.200 |
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