CAS number：372196-67-3 molecular formula：C16H14BrN5O4S
PIK-75游离碱是PI 3-激酶p110α的选择性抑制剂（PI 3-激酶p110α，PI 3-激酶p110γ和PI 3-激酶p110β的IC50值分别为5.8、76 nM和1.3μM）。抑制脂肪细胞中PIP2和PIP3的产生，Akt的磷酸化以及mTORC1的激活。细胞可渗透的。 PIK-75, free base is a selective inhibitor of PI 3-kinase p110α (IC50 values are 5.8, 76 nM and 1.3 μM at PI 3-kinase p110α, PI 3-kinase p110γ and PI 3-kinase p110β respectively). Inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and activation of mTORC1. Cell-permeable.
| Chinese alias | - | ||
| English alias | N'-[(1E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride | DS-15894 | N-[(E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide | NCGC00346500-05 | UNII-9058I | ||
| CAS number | 372196-67-3 | molecular formula | C16H14BrN5O4S |
| molecular weight | 452.28 g/mol | Exact mass | - |
| PSA | 121.000 Ų | logp | 3.800 |
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