WM-3835 是一种有效的，高特异性 HBO1 (KAT7 or MYST2) 抑制剂，可直接与 HBO1 33 的乙酰辅酶 A 结合位点结合 WM-3835 激活细胞凋亡，同时抑制骨肉瘤 (OS) 细胞的增殖，迁移和侵袭。WM-3835 具有抗肿瘤活性，并有效抑制小鼠中骨肉瘤异种移植物的生长。 Information WM-3835 WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. Targets KAT7 In vitro WM-3835 activates apoptosis while inhibites OS cell proliferation, migration and invasion. The activity of WM-3835 is ified in HBO1-KO OS cells. Also, the HBO1 inhibitor is non-cytotoxic in HBO1-low human osteoblasts, which indicates that the anti-OS cell efficacy of WM-3835 is primarily through HBO1 inhibition. In vivo intraperitoneal injection of a single dose of WM-3835 potently inhibites OS xenograft growth in SCID mice. Cell Research(from reference) Cell lines：Primary human OS cells (pOS-1 cells, pOS-2 cells) Concentrations：1 μM, 5 μM, 10 μM, 25 μM Incubation Time：24 h, 48 h, 72 h, 96 h
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WM-3835
CAS number：2229025-70-9 molecular formula：C20H17FN2O4S
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| Chinese alias | - | ||
| English alias | [1,1'-Biphenyl]-3-carboxylic acid,4-fluoro-5-methyl-,2-[(3-hydroxyphenyl)sulfonyl]hydrazide | ||
| CAS number | 2229025-70-9 | molecular formula | C20H17FN2O4S |
| molecular weight | 400.42 g/mol | Exact mass | 10mM in DMSO |
| PSA | 104.000 Ų | logp | 3.800 |
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