SRS11-92 是一种铁死亡抑制剂和 Ferrostatin-1 的衍生物。它抑制 Erastin 诱导的 HT-1080 人纤维肉瘤细胞铁致细胞死亡，EC50为6 nM。 Information SRS11-92 SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis . SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM. Targets HT-1080 ferroptotic cell death (Cell-based assay) 6 nM(EC50) In vitro SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts. Cell Research(from reference) Cell lines：murine I154F FRDA fibroblasts Concentrations：50 μM to 500 nM Incubation Time：48 h
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SRS11-92
CAS number：1467047-25-1 molecular formula：C22H28N2O2
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| Chinese alias | - | ||
| English alias | AA9Benzoic acid,4-(cyclohexylamino)-3-[(phenylmethyl)amino]-,ethyl ester | ||
| CAS number | 1467047-25-1 | molecular formula | C22H28N2O2 |
| molecular weight | 352.47 g/mol | Exact mass | 10mM in DMSO |
| PSA | 50.400 Ų | logp | 5.400 |
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