compound introduction
Inavolisib (GDC-0077, RG6114, RO-7113755) 是一种有效的 PI3K alpha (PI3Kα) 选择性抑制剂，IC50 为 0.038 nM。GDC-0077 对 PI3K α 的选择性比其他 I 类 PI3K 异构体（β、δ 和 γ）高 300 倍以上，对 PIK 家族成员的选择性高 2000 倍以上。GDC-0077 可与 PI3K 的 ATP 结合位点结合并抑制 PIP2 磷酸化为 PIP3。
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GDC-0077
CAS number：2060571-02-8 molecular formula：C18H19F2N5O4
overview
Specs
| Chinese alias | - | ||
| English alias | (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide | GDC0077 | GDC-0077 | INAVOLISIB [WHO-DD] | MS-26989 | AKOS040741785 | DB15275 | AMY16810 | Inavolisib [USAN] | O-Methyl Hydroxy | ||
| CAS number | 2060571-02-8 | molecular formula | C18H19F2N5O4 |
| molecular weight | 407.37 g/mol | Exact mass | - |
| PSA | 112.000 Ų | logp | 1.5 |
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