CAS number：1351635-67-0 molecular formula：C25H24N6O3
Information ONO-4059 analogue ONO-4059 analogue (ONO-WG-307) is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1. Targets BTK 23.9 nM In vitro In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.
| Chinese alias | - | ||
| English alias | ONO-WG-307(S)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one | ||
| CAS number | 1351635-67-0 | molecular formula | C25H24N6O3 |
| molecular weight | 456.5 g/mol | Exact mass | ≥98% |
| PSA | 105.000 Ų | logp | 3.38 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
