Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis In Vitro Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells Concentration: 20 μM, 40 μM , 60 μM , 80 μM Incubation Time: 48 hours Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion. In Vivo Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells) Dosage: 40 mg/kg Administration: Given i.p., each day for 13 days Result: Exhibited anti-tumor activity as a single-agent. Form:Solid IC50& Target:Bax
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Bax activator-1
CAS number：1638526-94-9 molecular formula：C29H36N4O3
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| Chinese alias | Bax激活剂-1 | ||
| English alias | - | ||
| CAS number | 1638526-94-9 | molecular formula | C29H36N4O3 |
| molecular weight | 488.62 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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