Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage. In Vitro cjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells. cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: U2OS Concentration: 0.5, 1, and 5 μM Incubation Time: 48 hours Result: Dose-dependent restoration of p53 levels (comparable to mock transfected cells) and inhibited gankyrin-induced lowering of p53 levels in cells. Form:Solid
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Cjoc42
CAS number：2171519-89-2 molecular formula：C20H21N3O5S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2171519-89-2 | molecular formula | C20H21N3O5S |
| molecular weight | 415.46 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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