Polygalacin D

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin , cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K . Polygalacin D induces apoptosis In Vitro Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC 50 s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells. Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells. Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM, 40µM Incubation Time: 48 hours Result: Inhibited the proliferation of NSCLC cell lines. Apoptosis AnalysisCell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Induced apoptosis of NSCLC cell lines. Western Blot AnalysisCell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression. Form:Solid IC50& Target:IC50: IAP

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