compound introduction
Spastazoline 是spastin(一种微管切断AAA 蛋白) 的选择性抑制剂，对人 spastin 的IC50值为 99 nM。它不能影响重组人 VPS4 的 ATPase 活性。 Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ). Information Spastazoline is a potent, cell-permeable and selectivespastin (a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein)inhibitor with IC50 of 99 nM for Human spastin. Spastazoline does not inhibit ATPase activity of a recombinant human VPS4 (another AAA protein required for intercellular bridge disassembly).
