CAS number：2262452-06-0 molecular formula：C19H12Cl2N4O3
Information RU.521 RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM. Targets cGAS/dsDNA complex (Cell-free assay); cGAS (Cell-free assay) 36.2 nM(Kd); 700 nM
| Chinese alias | - | ||
| English alias | RU320521 | 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one | ||
| CAS number | 2262452-06-0 | molecular formula | C19H12Cl2N4O3 |
| molecular weight | 415.23 g/mol | Exact mass | 10mM in DMSO |
| PSA | 87.300 Ų | logp | 4.828 |
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