Information Telratolimod Telratolimod (3M-052, MEDI9197) is an agonist of toll-like receptor 7 (TLR-7) and toll-like receptor 8 (TLR-8) with antitumor activity. Targets TLR7 ; TLR8 In vitro 3M-052 induces both TNFα and IFNα in human PBMCs in a manner indicative of a dual TLR7/TLR8 agonist. 3M-052 stimulates the production of IL8 in HEK293 cells stably expressing either human TLR7 or TLR8. In contrast, no IL8 is stimulated in empty vector control cells. The TLR8 agonist activity of 3M-052 may be of particular value in the immunization of neonates and infants whose monocytes and antigen presenting cells have a diminished capacity to generate TH1 polarizing signals to TNFα and IFNα. In vivo The co-administering CpG ODN with Telratolimod (3M-052) is remarkably effective at eliminating large established tumors and establishes long-term protective immunity. This anti-tumor activity is associated with a significant diminution in the frequency of tumor resident MDSC and accumulation of tumor-lytic NK and CD8 T cells, resulting in persistent anti-tumor immunity. Cell Research(from reference) Cell lines：PBMCs Concentrations：0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 0.01 μM, 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time：16 h
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Telratolimod
CAS number：1359993-59-1 molecular formula：C36H59N5O2
overview
compound introduction
Specs
| Chinese alias | N-(4-((4-氨基-2-丁基-1H-咪唑并[4,5-c]喹啉-1-基)氧基)丁基)硬脂酰胺 | 特拉托利莫德 | ||
| English alias | AKOS032946368 | N-(4-((4-Amino-2-butyl-1H-imidazo(4,5-C)quinolin-1-yl)oxy)butyl)octadecanamide | RRTPWQXEERTRRK-UHFFFAOYSA-N | N-(4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)oxy)butyl)stearamide | SCHEMBL671176 | s9623 | TELRATOLIMOD [INN] | N-(4-{ | ||
| CAS number | 1359993-59-1 | molecular formula | C36H59N5O2 |
| molecular weight | 593.89 g/mol | Exact mass | ≥97% |
| PSA | 95.100 Ų | logp | 11.9 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
