Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research. In Vitro Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides Dosage: 4 mg/kg Administration: Orally gavage; twice per day; for 7 days Result: Led to improved Y maze performance. Form:Solid
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Q134R
CAS number：2022949-46-6 molecular formula：C22H17F3N4O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2022949-46-6 | molecular formula | C22H17F3N4O |
| molecular weight | 410.39 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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