Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory. In Vitro Cell Viability AssayCell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Has no effect on cell cytotoxicity and inhibits NO production Western Blot AnalysisCell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreases p-ERK and p-JNK expression. RT-PCRCell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner. In Vivo Animal Model: Mice Dosage: 0.5 mg/kg Administration: Oral administration; 0.5 mg/kg/day; 17 days Result: Reinforced object recognition memory. Form:Solid
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Ciwujianoside C3
CAS number：114906-74-0 molecular formula：C53H86O21
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| Chinese alias | 刺五加苷C3 | ||
| English alias | - | ||
| CAS number | 114906-74-0 | molecular formula | C53H86O21 |
| molecular weight | 1059.24 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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