As a member of the Serpin superfamily of serine protease inhibitors, Serpin E1/PAI 1 is the principal inhibitor of urokinase type plasminogen activator (uPA) and tissue type PA. As important regulators of extracellular matrix remodeling, uPA and PAI 1 play a major role in many processes such as angiogenesis, tumor invasion, and obesity. For example, uPA and PAI-1 are the only tumor prognostic factors validated at the highest level of evidence with regard to their clinical utility in breast cancer. The human PAI-1 is initially synthesized as 402 amino acid precursor with an N terminal signal peptide. PAI 1 may exist in one of two possible conformations, designated as active or latent. The purified rhPAI 1 is active against rhuPA. The heterogeneity at the N terminus of the purified rhPAI 1 has been observed before for both the recombinant and native proteins.
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Recombinant Human Serpin E1/PAI-1 Protein
CAS number：unknown molecular formula：
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| Chinese alias | 重组人Serpin E1/PAI-1蛋白 | 重组人类 Serpin E1/PAI-1 蛋白 | ||
| English alias | Endothelial plasminogen activator inhibitor | Nexin | PAI1 | PAI-1 | PAI1PAI-1 | PAISerpin E1 | PLANH1 | PLANH1plasminogen activator inhibitor 1 | serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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