免疫球蛋白G1(IgG1),人骨髓瘤血浆,FC片段

由两个免疫球蛋白重链的羧基末端半部分组成的可结晶片段，通过二硫键相互连接。Fc片段包含重链恒定区的羧基末端部分，负责免疫球蛋白的效应功能（补体固定、通过Fc受体结合细胞膜和胎盘转运）。据报道，IgG1 FC作为治疗人类自身免疫性疾病的潜在抗炎药物具有新的作用。 IgG1 FC片段不结合抗原；然而，它确实包含经典的抗原决定簇和细胞营养反应、补体结合和分解代谢率控制方面的生物活性。 由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。 Ref.: Anthony R, Ravetch J, et al. (2010), J Clin Immunol. 30 Suppl 1:S9-14 Crystallizable fragments composed of the carboxy-terminal halves of both Immunoglobulins Heavy Chains linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (Complement fixation, binding to the cell membrane via FC Receptors, and placental transport). IgG1 FC was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases. The IgG1 FC fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to cytotrophic reactions, binding of complement and catabolic rate control. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Ref.: Anthony R, Ravetch J, et al. (2010), J Clin Immunol. 30 Suppl 1:S9-14

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