Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril. Rentiapril is an angiotensin converting enzyme ( ACE ) inhibitor. In Vivo A three-months toxicity study of an angiotensin converting enzyme (ACE) inhibitor, Rentiapril (CAS 80830-42-8), is performed in Sprague-Dawley rats by oral administration. The dose levels of 0, 30, 125, 500 and 1000 mg/kg are tested in both sexes, in which each experimental group comprised 10 rats. Another ACE inhibitor, captopril, is used as a reference compound. Rentiapril at the highest dose of 1000 mg/kg causes low food consumption and death of some animals with signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume and serum BUN level, and decreases in levels of various erythrocytic parameters. Kidney weight is increased dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia and interstitial cell infiltration. Similar, but mild, changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decrease bone marrow erythropoiesis and hepatocytic vacuolar degeneration. There is no pathological alteration in rats from other Rentiapril-treated groups, as well as in controls. These results indicate that the no-effect dose of Rentiapril in rats by three months oral administration is 30 mg/kg in female and 125 mg/kg in male . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Angiotensin converting enzyme (ACE)
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Rentiapril racemate
CAS number：72679-47-1 molecular formula：C13H15NO4S2
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| Chinese alias | 伦替普利消旋体 | ||
| English alias | DTXSID10868597 | 2-(2-hydroxyphenyl)-3-(3-mercaptopropanoyl)thiazolidine-4-carboxylic acid | 2-(2'-Hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid | SA 446 | AKOS040742537 | 4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mer | ||
| CAS number | 72679-47-1 | molecular formula | C13H15NO4S2 |
| molecular weight | 313.39 g/mol | Exact mass | ≥98% |
| PSA | 104.000 Ų | logp | 1.300 |
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