PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC 50 of 480 nM for human PARP10 . PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC 50 s of 1.7 μM for human PARP2 and human PARP15 , respectively In Vitro PARP10-IN-3 (compound 20) has an IC 50 of 1-2 μM by olony‐formation assay (CFA) in HeLa‐PARP10 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:human PARP10 480 nM (IC 50 ) human PARP2 1.7 μM (IC 50 ) human PARP15 1.7 μM (IC 50 ) human TNKS2 6.5 μM (IC 50 ) human PARP4 7 μM (IC 50 ) human TNKS1 21 μM (IC 50 ) human PARP14 41 μM (IC 50 ) human PARP12 >10 μM (IC 50 ) human PARP16 >10 μM (IC 50 ) human PARP1 >100 μM (IC 50 ) human PARP3 >100 μM (IC 50 )
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PARP10-IN-3
CAS number：2225800-19-9 molecular formula：C14H12N2O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2225800-19-9 | molecular formula | C14H12N2O3 |
| molecular weight | 256.26 g/mol | Exact mass | - |
| PSA | - | logp | - |
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