AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils ( K d = 2.3 nM) In Vivo Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue . AZD4694 (4 mL/kg; intravenous injection) inhibits [ 3 H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague–Dawley rats (275-300 g) Dosage: 4 mL/kg Administration: I.v. Result: Inhibited [ 3 H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. Form:Solid IC50& Target:Kd: 2.3 nM (Aβ)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
AZD4694
CAS number：1054629-49-0 molecular formula：C14H11FN2O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1054629-49-0 | molecular formula | C14H11FN2O2 |
| molecular weight | 258.25 g/mol | Exact mass | ≥99% |
| PSA | 58.300 Ų | logp | 3.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
