compound introduction
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC 50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC 50 of 1.05 μM. In Vitro The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans ). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC 50 =0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC 50 =1.05 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:5-Lipoxygenase 1.05 μM (IC 50 )
