TUG-469 is a selective free fatty acid receptor 1 ( FFA1/GPR40 ) agonist with an EC 50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes. In Vitro TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC 50 value of 7.73. TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation. TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC 50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively. TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male NZO mice with glucose administrationDosage: 5 mg/kg Administration: Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration Result: Reduced the blood glucose level. Form:Solid
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TUG-469
CAS number：1236109-67-3 molecular formula：C23H23NO2
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| Chinese alias | - | ||
| English alias | 3-[4-[[3-(2-methylphenyl)phenyl]methylamino]phenyl]propanoic acid | 3-(4(2''-Methylbiphenyl-3-ylmethylamino)phenyl)propanoic acid | Benzenepropanoic acid, 4-(((2'-methyl(1,1'-biphenyl)-3-yl)methyl)amino)- | 3-(4-((3-(2-Methylphenyl)phenyl)methylamino)phen | ||
| CAS number | 1236109-67-3 | molecular formula | C23H23NO2 |
| molecular weight | 345.43 g/mol | Exact mass | ≥99% |
| PSA | 49.300 Ų | logp | 5.100 |
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