compound introduction
MK-8189 is a potent, orally active and selective PDE10A inhibitor with a K i value of 29 pM. MK-8189 can be used in research of schizophrenia In Vivo MK-8189 (0.25-0.75 mg/kg; po) attenuates rats' locomotor activity in a dose-dependent manner . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar-Hannover rats Dosage: 0.25, 0.5, and 0.75 mg/kg Administration: Oral administration Result: Improved identification ability relative to the vector handling animal. Form:Solid IC50& Target:PDE10A 29 pM (Ki)
