SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase In Vitro SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED 50 , 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid IC50& Target:Sigma ligand
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
SR-31747 free base
CAS number：132173-06-9 molecular formula：C23H34ClN
overview
compound introduction
Specs
| Chinese alias | SR-31747 游离碱 | ||
| English alias | UNII-G622F7P8LU | Cyclohexanamine, N-(3-(3-chloro-4-cyclohexylphenyl)-2-propenyl)-N-ethyl-, (Z)- | SCHEMBL6652640 | C23H34ClN | 3-(3-chloro-4-cyclohexylphenyl)-n-cyclohexyl-n-ethyl-2(z)-propenylamine | AKOS015924573 | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl | ||
| CAS number | 132173-06-9 | molecular formula | C23H34ClN |
| molecular weight | 359.98 g/mol | Exact mass | - |
| PSA | 3.200 Ų | logp | 7.700 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
