PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer In Vitro PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker. PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC 50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: ZR75-1, T47D and MCF7 cells Concentration: 0~1 μM Incubation Time: 1 day Result: Down-regulated the expression of H3K23Ac biomarker. In Vivo PF-9363 shows strong anti-tumor activity in patient-derived xenograft models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:KAT6A/KAT6B
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PF-9363
CAS number：2569009-58-9(DMSO) molecular formula：C20H20N4O6S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2569009-58-9(DMSO) | molecular formula | C20H20N4O6S |
| molecular weight | 444.46 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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