BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP 4 receptor antagonist, with a pK B of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache In Vitro BGC-20-1531 free base competitively antagonized PGE 2 -induced vasodilatation of human middle cerebral (pK b =7.8) and meningeal (pK b =7.6) arteries, but had no effect on responses induced by PGE 2 on coronary, pulmonary or renal arteries. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Beagle dogs Dosage: 1-10 mg/kg Administration: I.v. Result: Caused a dose-dependent antagonism of the PGE 2 -induced increase in canine carotid blood flow. Form:Solid IC50& Target:EP4 7.6 (pKd)
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BGC-20-1531 free base
CAS number：736183-35-0 molecular formula：C26H24N2O6S
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| Chinese alias | BGC-20-1531 游离碱 | ||
| English alias | 9QV7JG4XYZ | 4-((4-(5-Methoxypyridin-2-yl)phenoxy)methyl)-5-methyl-N-(o-tolylsulfonyl)furan-2-carboxamide | 4-{[4-(5-methoxypyridin-2-yl)phenoxy]methyl}-5-methyl-N-(2-methylbenzenesulfonyl)furan-2-carboxamide | 4-[[4-(5-methoxypyridin-2-yl)phenoxy]methyl] | ||
| CAS number | 736183-35-0 | molecular formula | C26H24N2O6S |
| molecular weight | 492.54 g/mol | Exact mass | ≥98% |
| PSA | 116.000 Ų | logp | 4.500 |
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