NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ ( IC 50 =7.5 µM for hPTPRZ1) and PTPRG ( IC 50 =4.8 µM for hPTPRG) over other PTPs. NAZ232 IC50& Target:IC50: 7.5 µM (PTPRZ), 4.8 µM (PTPRG), 35.7 µM (PTPRA), 56.7 µM (PTPRM), 23.7 µM (PTPRS), 35.4 µM (PTPRB), 15.2 µM (PTPN6), 14.5 µM (PTPN1) In Vitro:NAZ2329 (0-25 µM; 48 hours) dose-dependently inhibits cell proliferation and migration in all cell lines (rat glioblastoma cells bearing C6 clone and human U251 glioblastoma cells). NAZ2329 (25 µM; 0-90 min) obviously promotes the phosphorylation lev In Vivo:NAZ2329 (22.5mg/kg; intraperitoneal injection; twice per week; 40 days) alone has a moderate inhibitory effect. However, the combination of Temozolomide and NAZ2329 exerts a significantly increased inhibition of tumor growth compared with the control gro Biological Activity:NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ ( IC 50 =7.5 µM for hPTPRZ1) and PTPRG ( IC 50 =4.8 µM for hPTPRG) over other PTPs. NAZ232
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NAZ2329
CAS number：unknown molecular formula：C21H18F3NO4S3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H18F3NO4S3 |
| molecular weight | 501.56 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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