Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor ( IC 50 =50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC 50 =200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation. Appearance:Solid IC50& Target:p300 50-500 nM (IC 50 ) In Vitro:Lys-CoA TFA (0.1 and 1 mM; 60 hours) induces a senescent phenotype in human normal melanocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Normal human melan Biological Activity:Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor ( IC 50 =50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC 50 =200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation.
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Lys-CoA TFA
CAS number：unknown molecular formula：C33H54F3N10O21P3S
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| Chinese alias | 赖氨酸辅酶A | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C33H54F3N10O21P3S |
| molecular weight | 1108.82 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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