RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively. IC50& Target:hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki) In Vitro:RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:RF9 (0.1mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoke Biological Activity:RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively .
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RF9 hydrochloride
CAS number：unknown molecular formula：C26H39ClN6O3
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| Chinese alias | RF9 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C26H39ClN6O3 |
| molecular weight | 519.08 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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