Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK . Emprumapimod hydrochloride can be used for the research of dilated cardiomyopathy and acute inflammatory pain. Appearance:Solid IC50& Target:p38α In Vitro:Emprumapimod hydrochloride (ARRY-797) inhibits LPS-induced IL-6 production in RPMI-8226 cell with an IC 50 value of 100 pM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:Emprumapimod hydrochloride (ARRY-797) (30mg/kg; p.o.) inhibits the expression of IL-6 (91%) and TNF-α (95%) in SCID-beige mice, inhibits the phosphorylation of p38 in RPMI-8226 xenografts, inhibits the growth of RPMI-8226 tumour (72%) in multiple myeloma Biological Activity:Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK . Emprumapimod hydrochloride can be used for the research of dilated cardiomyopathy and acute inflammatory pain .
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Emprumapimod hydrochloride
CAS number：unknown molecular formula：C24H30ClF2N5O3
overview
compound introduction
Specs
| Chinese alias | 盐酸恩普莫德 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C24H30ClF2N5O3 |
| molecular weight | 509.98 g/mol | Exact mass | - |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
