compound introduction
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC 50 s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively. Appearance:Solid IC50& Target:IC50: 56 nM(B-RAF), 7 nM(B-RAFv 600E ), 5 nM(C-RAF) . In Vitro:Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC 50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DD Biological Activity:Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC 50 s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv 600E and C-RAF respectively.
