PARP7-IN-14 (I-1) is a potent and selective PARP7 inhibitor with an IC 50 value of 7.6 nM. PARP7-IN-14 has anticancer activity. Appearance:Solid In Vitro:PARP7-IN-14 (I-1) inhibits CT26 cell lines with the IC 50 value of 12.85 μM and shows some anti-proliferative effect on tumors. PARP7-IN-14 (I-1) (0-4 μM) promotes mRNA expression levels of IFN-β and CXCL10 and induces a concentration-dependent incre In Vivo:PARP7-IN-14 (I-1) (p.o., 25-100mg/kg, twice daily, 14 days) significantly inhibits tumour growth in CT26 tumour-bearing mice, with a 67% reduction in mean tumour volume in mice treated with I-1 compared to controls, and does not cause weight loss or othe Biological Activity:PARP7-IN-14 (I-1) is a potent and selective PARP7 inhibitor with an IC 50 value of 7.6 nM. PARP7-IN-14 has anticancer activity.
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PARP7-IN-14
CAS number：unknown molecular formula：C21H24F6N8O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H24F6N8O2 |
| molecular weight | 534.46 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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