Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic Appearance:Solid IC50& Target:Ki: 12.2 nM (Neutrophil elastase) In Vitro:Simulated extracorporeal circulation is established by recirculating fresh heparinized (3.75 U/mL) human blood for 120 minutes in a membrane oxygenator and a roller pump with and without 1.0 μM of Freselestat (ONO-6818). Neutrophil elastase levels are sig In Vivo:Freselestat (ONO-6818; 10-100mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits Biological Activity:Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic
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Freselestat quarterhydrate
CAS number：unknown molecular formula：C23H28N6O4.1/4H2O
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| Chinese alias | 氟塞司他四分之一水合物 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C23H28N6O4.1/4H2O |
| molecular weight | 457.03 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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