compound introduction
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B . ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells. Appearance:Solid IC50& Target:IC50: 0.21 µM (ABHD17B) In Vitro:ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells. ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells. MCE has not independently confirmed the accuracy of these meth Biological Activity:ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B . ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells.
