compound introduction
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) . Appearance:Solid In Vivo:Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice. Lonodelestat (POL6014, 0.1, 0.5, 2 and 10mg/kg, intranasally administered) dose-dependently and significantly reduces the number of m Biological Activity:Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).
