G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM. Appearance:Solid In Vitro:G-5555 shows excellent kinase selectivity and inhibits only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. The IC 50 s of G-5555 against SIK2, PAK2, KHS1, MST4, YSK1, MST3 and L In Vivo:G-5555 exhibits low blood clearance and an acceptable half-life. Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) are achieved. In an H292 non-small cell lunger cancer (NSCLC) xenograft study in mice, G-5555 inhibits phosphoryla Biological Activity:G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM.
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G-5555 hydrochloride
CAS number：unknown molecular formula：C25H26Cl2N6O3
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| Chinese alias | G-5555 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C25H26Cl2N6O3 |
| molecular weight | 529.42 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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