SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 ( K i =0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-, κ- and δ-receptors with K i values of Appearance:Solid IC50& Target:NOP Receptor/ORL1 In Vivo:SB-612111 hydrochloride (intravenous injection; 0.6-10 nmol/mouse) antagonize nociceptin-induced thermal hyperalgesia in a dose-dependent manner with an ED 50 of 0.62mg/kg. SB-612111 hydrochloride (intravenous injection; 0.1-5mg/kg) causes a signif Biological Activity:SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 ( K i =0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-,xa0κ- andxa0δ-receptors with K i value
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SB-612111 hydrochloride
CAS number：unknown molecular formula：C24H30Cl3NO
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| Chinese alias | SB-612111盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C24H30Cl3NO |
| molecular weight | 454.86 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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