compound introduction
HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC 50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively. IC50& Target:IC50: 0.65 μM (HCoV-229E) In Vitro:HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner. HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis. MCE has not independe Biological Activity:HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC 50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively.
