3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activ Appearance:Solid In Vitro:3,6-DMAD hydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines. 3,6-DMAD hydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner In Vivo:3,6-DMAD hydrochloride (10mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo. 3,6-DMAD hydrochloride (10mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mic Biological Activity:3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activ
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3,6-DMAD hydrochloride
CAS number：unknown molecular formula：C22H31N5
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Specs
| Chinese alias | 3,6-DMAD 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H31N5 |
| molecular weight | - | Exact mass | ≥99% |
| PSA | - | logp | - |
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