Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by di Appearance:Viscous liquid IC50& Target:Ki: 5.1±1.2 nM (rat GABA B ), 1.4±0.3 μM (rat GABA A ) EC50: 8.6±0.77 nM (human GABA B receptor) In Vitro:Lesogaberan hydrochloride (3-30 nM) enhances human islet cell proliferation in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Human islet cells Concentrat In Vivo:Lesogaberan hydrochloride potently stimulates recombinant human GABA B receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) in dogs, with a biphasic dose-response curve. Oral Lesogaberan (0.08 mg/mL; 48 hours) hydrochloride Biological Activity:Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by di
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Lesogaberan hydrochloride
CAS number：unknown molecular formula：C3H10ClFNO2P
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| Chinese alias | 盐酸莱索加贝兰 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C3H10ClFNO2P |
| molecular weight | 177.54 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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