Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K i of 4.4 μM for rat small intestine NK-2 receptor. Appearance:Solid IC50& Target:Ki: 4.4 μM (NK-2 receptor, rat small intestine) In Vitro:Men 10376 is a selective tachykinin NK-2 receptor, with a K i of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (K i , >10 μM). Men 10376 shows pA 2 s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprive In Vivo:Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K i of 4.4 μM for rat small intestine NK-2 receptor.
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Men 10376 TFA
CAS number：unknown molecular formula：C59H69F3N12O12
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C59H69F3N12O12 |
| molecular weight | 1195.25 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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